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rex [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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rex [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

transcriptional repressor of anaerobically expressed genes involved in anaerobic respiration and fermentation
locus
BSU05970
pI
6.00
mw
23.00 kDa
function
regulation of fermentation and anaerobic respiration
product
transcriptional repressor
essential
no
synonyms
ydiH
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.1|Regulators of electron transport]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.1|Carbon core metabolism] → [category|SW 2.2.1.5|Overflow metabolism]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • [SW|Categories] containing this gene/protein

  • [SW|regulators of electron transport], [SW|carbon core metabolism], [SW|transcription factors and their control], [SW|sporulation/ other]

    • Gene

    Coordinates on the chromosome (coding sequence)
    647,091 -> 647,738

    Phenotypes of a mutant

  • inactivation of ''[SW|rex]'' reduces sporulation efficiency to 9.2% that of wild type cells [Pubmed|26735940]

    • The protein

    Protein family

  • transcriptional regulatory rex family (according to Swiss-Prot)

    • Effectors of protein activity

  • NADH (indication of low oxygen concentration) releases Rex from DNA [Pubmed|18485070], Rex has a very highh affinity for NADH

    • Structure

  • [PDB|2VT2], [PDB|2VT3]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|ydiG]-[protein|search|rex]-[SW|tatAY]-[SW|tatCY]'' [Pubmed|22383849]

    • Biological materials

    Mutant

  • MGNA-C201 (ydiH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2199 NBRP B. subtilis, Japan]
  • LUW292 (erm), GP834 (erm), both available in the [SW|Stülke] lab

    • Labs working on this gene/protein

  • [SW|Claes von Wachenfeldt], Lund University, Sweden [http://aron.ldc.lu.se/kundwebb/cellorg/mibiol/research/wachen/index.htm Homepage]

    • References

    Reviews

  • 23046954

    • Original publications

  • 16207915,18485070,15231791,17015645,20525796,21402078,22383849,25216269,26735940