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hemA [Tue Feb 09 2016 20:35:37 GMT+0100 (CET)]
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hemA [Tue Feb 09 2016 20:35:37 GMT+0100 (CET)]

glutamyl-tRNA reductase
locus
BSU28170
pI
5.00
mw
50.00 kDa
function
porphyrin biosynthesis
product
glutamyl-tRNA reductase
essential
no
ec
1.2.1.70
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|PerR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    2,877,766 -> 2,879,133

    The protein

    Catalyzed reaction/ biological activity

  • L-glutamate 1-semialdehyde NADP tRNA(Glu) = L-glutamyl-tRNA(Glu) NADPH (according to Swiss-Prot)

    • Protein family

  • glutamyl-tRNA reductase family (according to Swiss-Prot)

    • Structure

  • [PDB|4N7R] (from ''Arabidopsis thaliana'', 32% identity)

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|hemA]-[protein|search|hemX]-[protein|search|hemC]-[protein|search|hemD]-[protein|search|hemB]-[protein|search|hemL]'' [Pubmed|1672867]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1672867]

    • Regulation

  • induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]

    • Regulatory mechanism

  • [protein|search|PerR]: transcription repression [Pubmed|11532148]

    • References

  • 10217486,8012594,7667267,1536660,1672867,8932315,11532148