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katA [2017-04-24 15:34:12]
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katA [2017-04-24 15:34:12]

main vegetative catalase 1
locus
BSU08820
pI
6.15
mw
54.57 kDa
protein length
483 aa Sequence Blast
gene length
1449 bp Sequence Blast
function
detoxification (degradation) of hydrogen peroxide
product
vegetative catalase
essential
no
ec
1.11.1.6
synonyms
kat-19
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]

    • This gene is a member of the following [SW|regulons]

  • [SW|PerR regulon]

    • Gene

    Coordinates
    959,535 → 960,986

    Phenotypes of a mutant

  • increased sensitivity to oxidative stress [Pubmed|22174384]
  • increased susceptibility to Cr(VI) due to the accumulation of oxidative DNA damage [Pubmed|24973075]

    • The protein

    Catalyzed reaction/ biological activity

  • 2 H2O2 = O2 + 2 H2O (according to Swiss-Prot)

    • Protein family

  • catalase family (according to Swiss-Prot)

    • Modification

  • phosphorylated on Arg-366 [Pubmed|22517742]

    • [SW|Cofactors]

  • contains an iron-sulfur cluster, heme

    • Structure

  • [PDB|1SI8] (enzyme from Enterococcus faecalis, 68% identity)

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|B0A1AB6E920E6CBEE45115297599AF9A80972E38|katA]
    description
    [Pubmed|22174384]

    regulatory mechanism

  • [protein|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR]: repression, [Pubmed|11532148], in [regulon|00BCAAE16576DC5426A652580C69A570FC7A1C2C|PerR regulon]

    • regulation

  • induced in the presence of hydrogen peroxide and paraquat ([protein|search|PerR]) [Pubmed|11532148,22174384]
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    References

  • 9393707,7667267,8931328,8932315,11532148,22174384,22194458,22517742,24973075