similar to phage shock protein, resistance against oxidative stress and cell wall antibiotics (such as daptamycin)
function
resistance against oxidative stress and cell wall antibiotics
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics]This gene is a member of the following [SW|regulons]
[SW|LiaR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,397,846 -> 3,398,523
The protein
Protein family
pspA/IM30 family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|PspA][SW|Localization]
variable (spotty) protein [Pubmed|16479537]throughout the cytoplasm under non-inducing conditions [Pubmed|24666271]co-localizes with [protein|search|LiaI] in distinct static spots at the cytoplasma membrane under stress conditions [Pubmed|24666271][SW|Interactions]
forms large oligomeric rings with a nine-fold rotational symmetry [Pubmed|20639339][protein|search|LiaI]-[protein|search|LiaH] [Pubmed|24666271]Expression and Regulation
Operon
''[protein|search|liaI]-[protein|search|liaH]-[protein|search|liaG]-[protein|search|liaF]-[protein|search|liaS]-[protein|search|liaR]'' [Pubmed|14651641]''[protein|search|liaI]-[protein|search|liaH]'' [Pubmed|20639339][SW|Sigma factor]
[protein|search|SigA] [Pubmed|15273097]Regulation
induced by bacitracin and rhamnolipids ([protein|search|LiaR]) [Pubmed|16816187,22092710]induced by daptomycin [Pubmed|27791134]repressed during logarithmic growth ([protein|search|AbrB]) [PubMed|15101989,17660417], indirect regulation by [protein|search|AbrB] [Pubmed|20817675]Regulatory mechanism
[protein|search|LiaR]: transcription activation [Pubmed|16816187]References
Reviews
Original publications
19164152,15273097,20057163,16816187,15101989,17660417,16816187,20639339,16479537,20817675,22092710,24666271,27791134 
