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folB [Wed Feb 15 2017 18:06:10 GMT+0100 (CET)]
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folB [Wed Feb 15 2017 18:06:10 GMT+0100 (CET)]

dihydroneopterin aldolase
locus
BSU00780
pI
5.00
mw
13.00 kDa
function
biosynthesis of folate
product
dihydroneopterin aldolase
essential
yes
ec
4.1.2.25
synonyms
folA, yacE

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors]
  • Gene

    Coordinates on the chromosome (coding sequence)
    86,587 -> 86,949

    Phenotypes of a mutant

  • essential [Pubmed|28189581]
  • The protein

    Catalyzed reaction/ biological activity

  • 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine glycolaldehyde (according to Swiss-Prot)
  • Protein family

  • DHNA family (according to Swiss-Prot)
  • Structure

  • [PDB|1U68] (from ''Staphylococcus aureus'', 47% identity, 72% similarity) [Pubmed|15027862]
  • Expression and Regulation

    Operon

  • ''[protein|search|pabB]-[protein|search|pabA]-[protein|search|pabC]-[protein|search|sul]-[protein|search|folB]-[protein|search|folK]-[protein|search|yazB]-[protein|search|yacF]-[protein|search|lysS]'' [Pubmed|9084182]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9084182]
  • References

  • 9084182,28189581