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mrpB

Na⁺/H⁺ antiporter subunit, multiple resistance and pH homeostasis

locus

BSU_31610

4.91

15.15 kDa

protein length

143 aa Sequence Blast

gene length

432 bp Sequence Blast

function

sodium export

product

Na⁺/H⁺ antiporter subunit

essential

yes

synonyms

yufU

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]

[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export]

[category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates

3,248,996 3,249,427

Phenotypes of a mutant

essential [Pubmed|12682299]

The protein

Protein family

CPA3 antiporters (TC 2.A.63) subunit B family (single member, according to UniProt)

Structure

[PDB|6CFW] (from Pyrococcus furiosus, corresponds to aa 1 ... 104, 31% identity) [pubmed|29754813]

[SW|Localization]

cell membrane (according to UniProt)

Expression and Regulation

Operons

genes

description

[Pubmed|9274030,10198001]

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Biological materials

Mutant

MGNA-B558 (yufU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1557 NBRP B. subtilis, Japan]

SM-GN9 (mrpB-spc), available in [SW|Anne Galinier]'s and [SW|Boris Görke]'s labs

References

Reviews

29218041

Original publications

11004162,9274030,10198001,19389778,17693497,18408029,29754813