SubtiBank SubtiBank
tcyK [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

tcyK [Tue Dec 13 2016 11:16:35 GMT+0100 (CET)]

cystine ABC transporter (binding protein)
locus
BSU29370
pI
9.01
mw
30.00 kDa
function
cystine uptake
product
cystine ABC transporter (binding protein)
essential
no
synonyms
ytmK
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.2|Uptake of amino acids]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.9|Biosynthesis/ acquisition of cysteine]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|ABC transporters], [SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|CymR regulon], [SW|AscR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,006,600 -> 3,007,412

    The protein

    Protein family

  • bacterial solute-binding protein 3 family (according to Swiss-Prot)

    • Structure

  • [PDB|2O1M]

    • [SW|Localization]

  • attached to the membrane via [protein|search|TcyL]-[protein|search|TcyM] [Pubmed|10092453]

    • [SW|Interactions]

  • [protein|search|TcyN]-([protein|search|TcyL]-[protein|search|TcyM])-([protein|search|TcyJ]-[protein|search|TcyK]) [Pubmed|10092453]

    • Expression and Regulation

    Operon

  • ''[protein|search|snaA]-[protein|search|tcyJ]-[protein|search|tcyK]-[protein|search|tcyL]-[protein|search|tcyM]-[protein|search|tcyN]-[protein|search|cmoO]-[protein|search|cmoI]-[protein|search|cmoJ]-[protein|search|ribR]-[protein|search|sndA]-[protein|search|ytnM]'' [Pubmed|15668000]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|15272571]

    • Regulation

  • repressed in the presence of cysteine ([protein|search|CymR]) [Pubmed|16109943]
  • induced in the presence of S-methyl-cysteine ([protein|search|AscR]) [Pubmed|23944997]

    • Regulatory mechanism

  • [protein|search|CymR]: transcription repression [Pubmed|16109943]
  • [protein|search|AscR]: transcription activation [Pubmed|16109943]

    • Biological materials

    Mutant

  • 1A948 ( ''tcyK''::''kan''), [Pubmed|15262924], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A948&Search=1A948 BGSC]

    • References

  • 15262924,10092453,16109943,12193636,15668000,15272571,23944997