SubtiBank SubtiBank
nhaC
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nhaC

Na /H antiporter
locus
BSU_09680
pI
7.87
mw
47.89 kDa
protein length
453 aa Sequence Blast
gene length
1362 bp Sequence Blast
function
pH homeostasis
product
Na /H antiporter
essential
no
synonyms
yheL
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.2|Sodium uptake/ export]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.5|PH homeostasis]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    1,042,885 1,044,246

    The protein

    Protein family

  • NhaC Na(+)/H(+) (TC 2.A.35) antiporter family (with [protein|49DF23B8E19658DB32835B6D23DD21E4BF481B20|MleN], according to UniProt)

    • Paralogous protein(s)

  • [protein|49DF23B8E19658DB32835B6D23DD21E4BF481B20|MleN]

    • [SW|Localization]

  • cell membrane (according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]
    description
    [Pubmed|21815947]

    regulatory mechanism

  • [protein|D0BBFE1706429A98B7E93998794061A112FE8ECA|NhaX]: activation, (probably) [Pubmed|11274110], in [regulon|D0BBFE1706429A98B7E93998794061A112FE8ECA|NhaX regulon]

    • regulation

  • subject to indirect positive regulation by [protein|search|CodY] [Pubmed|24843172]

    • additional information

  • the mRNA is substantially stabilized upon depletion of [gene|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [PubMed|21815947]
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    Biological materials

    Mutant

  • MGNA-A707 (yheL::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/707 NBRP B. subtilis, Japan]
  • BKE09680 ([gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE09680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAATAACACCCCATATTT, downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA
  • BKK09680 ([gene|A7F1B4C0D32E18773170BFBEEB94E5EF55C7DB97|nhaC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK09680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAAAATAACACCCCATATTT, downstream forward: _UP4_TAAAAAGAGCCCCGCTGTAA

    • References

    Reviews

  • 27935846

    • Original publications

  • 11274110,21815947,24843172