transcriptional activator (MerR family) of multidrug-efflux transporter genes, activates ymfD expression
function
regulation of multidrug-efflux transporter genes
product
transcriptional activator (MerR family)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|resistance against toxins/ antibiotics]This gene is a member of the following [SW|regulons]
[SW|Mta regulon]Gene
Coordinates on the chromosome (coding sequence)
3,764,133 -> 3,764,906
The protein
Protein family
[SW|MerR family]Structure
[PDB|1JBG] (N-terminal domain), [PDB|1R8D] (complex of N-terminal domain with DNA)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''mta'' [Pubmed|9353933][SW|Sigma factor]
[protein|search|SigA] [Pubmed|10200972]Regulation
positive autoregulation [Pubmed|10200972]Regulatory mechanism
Mta: transcription activation [Pubmed|10200972]Labs working on this gene/protein
[SW|Mohamed Marahiel], Marburg University, Germany [http://www.uni-marburg.de/fb15/fachgebiete/bio/marahiel?language_sync=1 homepage][SW|Richard Brennan], Houston, Texas, USA [http://www.mdanderson.org/departments/biochem/display.cfm?id=556ef368-6c81-4043-b74f350d41dd06cb&method=displayfull&pn=a8427ebd-d0ff-11d4-80fd00508b603a14 Homepage]References
18502870,14985361,11581256,11053850,10200972,9353933 
