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capA
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capA

gamma-polyglutamate transporter,capsular polyglutamate biosynthesis, involved in controlling the D/L enantiomer ratio in polyglutamate
locus
BSU_35880
pI
9.27
mw
42.60 kDa
protein length
380 aa Sequence Blast
gene length
1143 bp Sequence Blast
function
capsular polyglutamate biosynthesis
product
gamma-polyglutamate transporter
essential
no
synonyms
ywtB,pgsA
Outlinks
KEGGBsubCycSubtiListUniProt

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.4|Capsule biosynthesis and degradation]

    • Gene

    Coordinates
    3,697,821 3,698,963

    The protein

    Protein family

  • CapA family (with [protein|8DCA50478136628DD9E5D01E89609A686EED9F57|TkmA] and [protein|F6C4634BF871D9A01E27014FFED7527C54BF560D|EpsA], according to UniProt)

    • Expression and Regulation

    Operons

    genes
    [gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]
    description
    [Pubmed|11751809]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|19420703], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]: activation, [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU]-P, [Pubmed|19734658], in [regulon|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU regulon]

    • additional information

  • expression of the operon is increased in '[protein|search|motA]' or '[protein|search|motB]' mutants due to increased [protein|search|DegU] phosphorylation [PubMed|24296669]
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    Biological materials

    Mutant

  • MGNA-B121 (pgsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1120 NBRP B. subtilis, Japan]
  • BKE35880 ([gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE35880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATCGTTTGACACACCT, downstream forward: _UP4_TCTAAATAATCGGAGTGATA
  • BKK35880 ([gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK35880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTTCATCGTTTGACACACCT, downstream forward: _UP4_TCTAAATAATCGGAGTGATA

    • References

    Reviews

  • 20735481,16689787,29215550

    • Original publications

  • 11751809,19420703,16233197,20564357,20564574,24296669,21965392,27073802,29971620,30295732,31837088,16278834