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ktrB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]
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ktrB [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

high affinity potassium transporter KtrA-KtrB, integral membrane subunit
locus
BSU31100
pI
10.00
mw
48.00 kDa
function
potassium uptake
product
high affinity potassium transporter KtrA-KtrB,
integral membrane subunit (proton symport)
essential
no
synonyms
yubG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.5|Metal ion transporter]
  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.1|Metal ion homeostasis (K, Na, Ca, Mg)] → [category|SW 1.3.1.3|Potassium uptake/ export]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|transporters/ other], [SW|metal ion homeostasis (K, Na, Ca, Mg)], [SW|coping with hyper-osmotic stress], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|YdaO riboswitch]

    • Gene

    Coordinates on the chromosome (coding sequence)
    3,189,089 -> 3,190,426

    The protein

    Paralogous protein(s)

  • [protein|search|KtrD]

    • Structure

  • [PDB|4J7C] (the [protein|search|KtrA]-[protein|search|KtrB] complex) [Pubmed|23598340]

    • [SW|Localization]

  • integral membrane protein [Pubmed|12562800]

    • [SW|Interactions]

  • KtrB forms dimers [Pubmed|17932047]
  • [protein|search|KtrA]-[protein|search|KtrB] [Pubmed|12562800], composed of an octameric [protein|search|KtrA] ring and two [protein|search|KtrB] dimers [Pubmed|23598340]

    • Expression and Regulation

    Operon

  • ''[protein|search|ktrA]-[protein|search|ktrB]'' [Pubmed|12562800]

    • Regulatory mechanism

  • expression is controlled via termination antitermination by the [SW|ydaO riboswitch], expression is switched off upon binding od c-di-AMP [Pubmed|24141192,20511502]

    • Biological materials

    Mutant

  • MGNA-A227 (yubG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/227 NBRP B. subtilis, Japan]
  • 1A954 ( ''ktrB''::''kan''), [Pubmed|12562800], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A954&Search=1A954 BGSC]
  • GHB1 (D(''[protein|search|ktrA]-[protein|search|ktrB]'')::''aphA3''), available in [SW|Erhard Bremer]'s lab
  • GP92 (D(''[protein|search|ktrA]-[protein|search|ktrB]'')::''aphA3''), available in [SW|Jörg Stülke]'s lab

    • Labs working on this gene/protein

  • [SW|Erhard Bremer], University of Marburg, Germany [http://www.uni-marburg.de/fb17/fachgebiete/mikrobio/molmibi homepage]

    • References

    Reviews

  • 25869574,21680052

    • Original publications

  • 12562800,20511502,17932047,23086297,23598340,16990138,24141192,26771197