transcriptional repressor, regulates zinc homeostasis
function
regulation of zinc homeostasis
(yciC, znuA-znuC-znuB)
product
transcriptional repressor (Fur family)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.2|Trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)] → [category|SW 1.3.2.3|Zinc][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|trace metal homeostasis (Cu, Zn, Ni, Mn, Mo)], [SW|transcription factors and their control], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
2,591,428 -> 2,591,865
The protein
Protein family
[SW|Fur family]Paralogous protein(s)
[protein|search|PerR], [protein|search|Fur]Modification
phosphorylated on ser/ thr/ tyr [Pubmed|16493705]Effectors of protein activity
sequential binding of zinc (two atoms per monomer) results in the activation of Zur and thus in repression of the genes of the [SW|Zur regulon] [Pubmed|21821657][SW|Interactions]
forms dimers [Pubmed|21821657]Biological materials
Mutant
1A904 ( ''zur''::''spec''), [Pubmed|12029044], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A904&Search=1A904 BGSC]Labs working on this gene/protein
[SW|John Helmann], Cornell University, USA [http://www.micro.cornell.edu/research/labs/helmann-lab/index.cfm Homepage]References
21821657,18344368,14563870,12904577,16493705,9811636,12426338,19648245,25649915 
