You are currently viewing an outdated version of
SubtiWiki.
Please use
the newest version!
thiM
hydroxyethylthiazole kinase
function
biosynthesis of thiamine
product
hydroxyethylthiazole kinase
synonyms
thiK,ipa-25d,ywbJ
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.3|Biosynthesis/ acquisition of thiamine]Gene
Coordinates
3,931,372 3,932,190
The protein
Catalyzed reaction/ biological activity
5-(2-hydroxyethyl)-4-methylthiazole + ATP --> 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H+ (according to UniProt)Protein family
Thz kinase family (single member, according to UniProt)Structure
[PDB|1C3Q]Expression and Regulation
Operons
genes
[gene|CC55120C2AF455FA2AEAE39E21F57897B2B5BC39|ywbI]-[gene|9B82059498F72A67282DD54892EF02A305E3C674|thiM]-[gene|8FAEB6342E087BEDC16FDF5585B03B90ACFF8D11|thiE]
description
[Pubmed|9139923]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9139923], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]view in new tabBiological materials
Mutant
BKE38300 ([gene|9B82059498F72A67282DD54892EF02A305E3C674|thiM]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTGCATCATCCTTTA, downstream forward: _UP4_TCATGACTCGTATTTCTCGGBKK38300 ([gene|9B82059498F72A67282DD54892EF02A305E3C674|thiM]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38300 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATTTGCATCATCCTTTA, downstream forward: _UP4_TCATGACTCGTATTTCTCGGReferences
Reviews
Original publications
