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rplB [Fri Jan 29 2016 16:45:25 GMT+0100 (CET)]
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rplB [Fri Jan 29 2016 16:45:25 GMT+0100 (CET)]

ribosomal protein L2, required for assembly of RplP into the 50S subunit of the ribosome
locus
BSU01190
pI
11.00
mw
30.00 kDa
function
translation
product
ribosomal protein L2 (BL2)
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|translation], [SW|essential genes], [SW|universally conserved proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|stringent response]

    • Gene

    Coordinates on the chromosome (coding sequence)
    137,311 -> 138,144

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]
  • a H142L mutation results in a temperature-sensitive phenotype and is acompanied by growth and [SW|sporulation] defects, the mutation can be suppressed by increased expression of ''[protein|search|yaaA]'' [Pubmed|24637032]

    • The protein

    Protein family

  • [SW|ribosomal protein] L2P family (according to Swiss-Prot)

    • Structure

  • [PDB|1RL2] (L2 RNA-binding domain, Geobacillus stearothermophilus)

    • [SW|Interactions]

  • [protein|search|RplB]-[SW|23S rRNA] [Pubmed|24637032]

    • Expression and Regulation

    Operon

  • ''[protein|search|rpsJ]-[protein|search|rplC]-[protein|search|rplD]-[protein|search|rplW]-[protein|search|rplB]-[protein|search|rpsS]-[protein|search|rplV]-[protein|search|rpsC]-[protein|search|rplP]-[protein|search|rpmC]-[protein|search|rpsQ]-[protein|search|rplN]-[protein|search|rplX]-[protein|search|rplE]-[protein|search|rpsN]-[protein|search|rpsH]-[protein|search|rplF]-[protein|search|rplR]-[protein|search|rpsE]-[protein|search|rpmD]-[protein|search|rplO]'' [Pubmed|9371452]

    • [SW|Sigma factor]

  • [protein|search|SigA] two promoters, about 140bp and 200bp upstream of the start codon [Pubmed|9371452]

    • Regulation

  • [protein|search|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]

    • References

  • 19653700,9371452,11948165,8635744,10075918,23249812,23002217,24637032