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folE2 [Sun Aug 28 2016 19:01:27 GMT+0200 (CEST)]

GTP cyclohydrolase IB, replaces FolE under conditions of zinc starvation

locus

BSU03340

7.00

34.00 kDa

function

biosynthesis of folate

product

zinc-independent GTP cyclohydrolase IB

essential

3.5.4.16

synonyms

yciA

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]

[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation]

[SW|Categories] containing this gene/protein

[SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

[SW|Zur regulon]

Gene

Coordinates on the chromosome (coding sequence)

364,259 -> 365,173

The protein

Catalyzed reaction/ biological activity

GTP H₂O = formate 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)

Protein family

GTP cyclohydrolase IV family (according to Swiss-Prot)

[SW|Cofactors]

activated by a variety of divalent cations [Pubmed|19767425]

Structure

[PDB|3D1T] [Pubmed|19767425]

[SW|Interactions]

homotetrameric [Pubmed|19767425]

Expression and Regulation

Operon

[SW|Sigma factor]

[protein|search|SigA] [Pubmed|12426338]

Regulation

induced by zinc starvation ([protein|search|Zur]) [Pubmed|12426338]

Regulatory mechanism

[protein|search|Zur]: transcription repression in the presence of zinc [Pubmed|12426338]

References

9811636,12426338,17032654,19767425