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lspA [2019-08-01 10:17:09]

signal peptidase II

locus

BSU_15450

9.13

17.28 kDa

protein length

154 aa Sequence Blast

gene length

465 bp Sequence Blast

function

protein secretion

product

signal peptidase II

essential

3.4.23.36

synonyms

lsp

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion]

[category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates

1,616,744 1,617,208

The protein

Catalyzed reaction/ biological activity

Release of signal peptides from bacterial membrane prolipoproteins (according to Swiss-Prot)

Protein family

peptidase A8 family (single member, according to UniProt)

Structure

[PDB|5DIR] (from Pseudomonas aeruginosa, 38% identity), [pubmed|26912896]

[SW|Localization]

cell membrane (according to UniProt)

Expression and Regulation

Operons

genes

description

[Pubmed|22383849]

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Biological materials

Mutant

BKE15450 ([gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE15450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAACGTTCCTCCAGTTT, downstream forward: _UP4_GGGAAAAAGAAAAAGGAGCA

BKK15450 ([gene|8FC1A0A6C9975F6C125490FBAAB2A4957210A9F1|lspA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK15450 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CACAAACGTTCCTCCAGTTT, downstream forward: _UP4_GGGAAAAAGAAAAAGGAGCA

References

9882689,10497172,9880550,26912896