primary bacitracin resistance determinant, ABC transporter (ATP-binding protein) for the export of bacitracin, plectasin, mersacidin and actagardine
function
export of toxic peptides
product
bacitracin ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.2|Exporters] → [category|SW 1.2.1.2.3|Export of peptides][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|BceR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,111,327 -> 3,112,088
The protein
Protein family
[SW|ABC transporter] family (according to Swiss-Prot)Effectors of protein activity
the activity of the [protein|search|BceA]-[protein|search|BceB] [SW|ABC transporter] is inhibited by heptaprenyl pyrophosphate which accumulates in a ''[protein|search|ytpB]'' mutant [Pubmed|24806199]Structure
[PDB|1L2T] (MJ0796 from '' Methanocaldococcus jannaschii '', 38% identity) [Pubmed|12150914][SW|Localization]
membrane associated (via [protein|search|BceB]) [Pubmed|12890034][SW|Interactions]
[protein|search|BceA]-[protein|search|BceB] [Pubmed|25118291,23687272]Expression and Regulation
Operon
''[protein|search|bceA]-[protein|search|bceB]'' [Pubmed|12890034]Regulation
induced in the presence of bacitracin, plectasin, mersacidin and actagardine ([protein|search|BceR]) [Pubmed|12890034]strongly induced in the stationary phase due to the internal production of toxic peptides ([SW|SdpC], [SW|SkfA]) ([protein|search|BceR]) [Pubmed|26364265]strong induction by [SW|SkfA], weaker induction by [SW|SdpC] [Pubmed|26364265]Regulatory mechanism
[protein|search|BceR]: transcription activation [Pubmed|12890034]Biological materials
Mutant
MGNA-A167 (ytsC::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/167 NBRP B. subtilis, Japan]Labs working on this gene/protein
Foglino M. [Pubmed|17905982]References
Reviews
Original publications
17905982,18394148,12890034,14651641,10092453,14612242,21283517,20606066,21078927,23687272,24806199,25118291,26199330,26364265,12150914,27997719 
