function
fatty acid biosynthesis
product
acyl carrier protein
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.1|Biosynthesis of fatty acids][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|FapR regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Structure
[PDB|1F80] (complex with [protein|search|AcpS]) [Pubmed|10997907], [PDB|3EJE] (complex with [protein|search|BioI]) [Pubmed|18838690], [PDB|1HY8][SW|Localization]
cytoplasm (according to Swiss-Prot), during sporulation in the mother cell [Pubmed|19850612][SW|Interactions]
[protein|search|AcpA]-[protein|search|AcpS] [Pubmed|10997907][protein|search|AcpA]-[protein|search|BioI] [Pubmed|18838690]malonyl-[AcpA|search|ACP]-[protein|search|FapR] [Pubmed|20201588]Expression and Regulation
Operon
''[protein|search|fapR]-[protein|search|plsX]-[protein|search|fabD]-[protein|search|fabG]-[protein|search|acpA]'' [Pubmed|19850612]''[protein|search|acpA]'' [Pubmed|19850612][SW|Sigma factor]
''[protein|search|fapR]'': [protein|search|SigA] [Pubmed|16932747]Regulation
''[protein|search|fapR]'': repressed in the absence of malonyl-CoA or malonyl-[AcpA|search|ACP] ([protein|search|FapR]) [Pubmed|12737802]strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]Regulatory mechanism
[protein|search|FapR]: transcription repression [Pubmed|12737802]Labs working on this gene/protein
[SW|Diego de Mendoza], Universidad Nacional de Rosario, Argentine [http://www.ibr.gov.ar/eng/investigacion/demendoza.htm homepage]References
Reviews
Original Publications
10997907,19850612,12737802,18838690,20201588,23033921 
