ABC transporter (ATP-binding protein) (FtsE-FtsX), required for CwlO activity (cell elongation) and for proper activation of Spo0A and initiation of sporulation
function
control of cell wall synthesis
product
ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.2|Autolytic activity required for peptidoglycan synthesis (cell elongation)][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.7|phosphorelay][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.2|phosphorelay][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ABC transporters], [SW|cell wall synthesis], [SW|phosphorelay], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|Spo0A regulon]Gene
Phenotypes of a mutant
a ''[protein|search|ftsE]'' mutation is synthetically lethal with a ''[protein|search|lytE]'' mutation (due to a lack of autolysin activity) [Pubmed|23869552,23855774]shorter, fatter cells, this can be rescued by addition of Mg(2+) [Pubmed|23869552,23855774]reduced growth rate, especially at low Mg(2+) concentrations [Pubmed|23869552]The protein
Catalyzed reaction/ biological activity
necessary for the autolysin activity of [protein|search|CwlO] [Pubmed|23855774]Structure
[PDB|3TIF] (ATP-binding protein from ''Methanococcus jannaschii'', 40% identity) [Pubmed|22158619][SW|Localization]
membrane associated (via [protein|search|FtsX]) [Pubmed|18573177][SW|Interactions]
[protein|search|FtsE]-[protein|search|FtsX] [Pubmed|18573177]Expression and Regulation
Operon
''[protein|search|ftsE]-[protein|search|ftsX]'' (according to [http://dbtbs.hgc.jp/COG/prom/ftsEX.html DBTBS])Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647]References
10092453,18573177,22158619,14651647,23855774,23869552 
