phosphoglycerate dehydrogenase
function
biosynthesis of serine
product
phosphoglycerate dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.8|Biosynthesis/ acquisition of serine/ glycine/ alanine][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins], [SW|most abundant proteins]Gene
Coordinates on the chromosome (coding sequence)
2,411,086 -> 2,412,663
The protein
Catalyzed reaction/ biological activity
3-phospho-D-glycerate NAD = 3-phosphonooxypyruvate NADH (according to Swiss-Prot) Protein family
D-isomer specific 2-hydroxyacid dehydrogenase family (according to Swiss-Prot)Modification
S-cysteinylation after diamide stress (C410)[Pubmed|17611193]active site Cys410 is S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species [Pubmed|21749987] [Pubmed|22938038]Structure
[PDB|1YBA] (from ''E. coli'', 30% identity, 52% similarity) [Pubmed|15823035][SW|Localization]
membrane [Pubmed|18763711]Expression and Regulation
Operon
''serA'' [Pubmed|7934830]Regulation
strongly repressed in response to glucose starvation in M9 medium [Pubmed|23033921]Additional information
belongs to the 100 [[most abundant proteins]] [PubMed|15378759]Biological materials
Mutant
1A614 ( ''serA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A614&Search=1A614 BGSC] and in [SW|Jörg Stülke]'s lablacZ fusion
pGP187 (in [protein|search|pAC7]), available in [SW|Jörg Stülke]'s labReferences
22938038,17611193,7934830,18763711,15823035,21749987,23033921,15378759 
