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ftsW [Fri Dec 16 2016 19:48:02 GMT+0100 (CET)]
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ftsW [Fri Dec 16 2016 19:48:02 GMT+0100 (CET)]

SEDS family peptidoglycan glycosyltransferase, cell-division protein
locus
BSU14850
pI
9.00
mw
43.00 kDa
function
cell division
product
SEDS family peptidoglycan glycosyltransferase
essential
yes
synonyms
ylaO
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|cell division], [SW|essential genes], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|YofA regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    1,552,899 -> 1,554,110

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • principal peptidoglycan glycosyltransferase of the [SW|divisome] [Pubmed|27525505]

    • Protein family

  • [SW|FtsW]/[SW|RodA]/[SW|SpoVE] family (according to Swiss-Prot)
  • [SW|SEDS proteins] (shape, elongation, division, and sporulation) [Pubmed|27525505]

    • Paralogous protein(s)

  • [protein|search|RodA], [SW|SpoVE]

    • [SW|Localization]

  • integral membrane protein
  • localizes to the division site [Pubmed|27895631]
  • localization depends on [SW|FtsZ] and [SW|FtsZ] [Pubmed|26679002]

    • [SW|Interactions]

  • [protein|search|Maf]-[protein|search|FtsW] [Pubmed|21564336]
  • may be part of the [SW|divisome] [Pubmed|26679002]

    • Expression and Regulation

    Operon

  • ''[protein|search|ftsW]-[protein|search|pycA]'' (according to [http://dbtbs.hgc.jp/COG/prom/ftsW-pycA.html DBTBS])

    • Regulation

  • constitutively expressed [Pubmed|23701187]

    • Regulatory mechanism

  • [protein|search|YofA]: transcription activation [Pubmed|17526699]

    • Biological materials

    Mutant

  • MGNA-A563 (ylaO::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/563 NBRP B. subtilis, Japan]

    • FLAG-tag construct

  • GP2007 ''ftsW-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab

    • References

    Reviews

  • 26679002

    • Original Publications

  • 17981970,19429628,17526699,21564336,23701187,27525505,27895631,17379809,27895631