SubtiBank SubtiBank
codV
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codV

site-specific integrase/recombinase, partitioning of the terminus region after replication
locus
BSU_16140
pI
9.31
mw
35.19 kDa
protein length
304 aa Sequence Blast
gene length
915 bp Sequence Blast
function
chromosome partitioning
product
site-specific integrase/recombinase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]

    • Gene

    Coordinates
    1,687,187 1,688,101

    The protein

    Catalyzed reaction/ biological activity

  • resolution of chromosome dimers by site specific recombination at the dif site (located close to the terminus region on the chromosome)

    • Protein family

  • [SW|phage integrase family] (according to UniProt)

    • Paralogous protein(s)

  • [protein|301568A5255A31538F52C46D7711EDAB2BD9CE90|RipX]

    • Structure

  • [PDB|1A0P] (from ''E. coli'', 39% identity, complex with [protein|301568A5255A31538F52C46D7711EDAB2BD9CE90|RipX]) [Pubmed|9311978]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)
  • assembles on the chromosome at the dif site throughout the cell cycle [Pubmed|21239579]

    • Expression and Regulation

    Operons

    genes
    [gene|B6062575849EA65BB7B44A9723676885799E2759|trmFO]-[gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]-[gene|F6B748621B312E0B5A0A0782F3944C3E8112D7A8|clpQ]-[gene|2A5A080273CB7698DFABB147F4143E90BBCA3B01|clpY]-[gene|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|codY]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7783641], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|11331605], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]

    • regulation

  • repressed during growth in the presence of branched chain amino acids ([protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]) [Pubmed|11331605]

    • additional information

  • the intracellular concentration of CodY is about 2.5 myM (according to [PubMed|20408793])
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    Biological materials

    Mutant

  • 1A794 ( ''codV''::''kan''), [Pubmed|10498718], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A794&Search=1A794 BGSC]
  • BKE16140 ([gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE16140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCTAATACCTCCCCAG, downstream forward: _UP4_AAGAAAAATTAAAGGAGGCC
  • BKK16140 ([gene|89746E312F20C81BE3CFDFCE7D99B01C375C198B|codV]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK16140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCCTAATACCTCCCCAG, downstream forward: _UP4_AAGAAAAATTAAAGGAGGCC

    • References

    Reviews

  • 23400100

    • Original publications

  • 10498718,16597952,11208805,11331605,7783641,21239579,9311978