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truA
pseudouridylate synthase I, universally conserved protein
function
tRNA modification
product
pseudouridylate synthase I
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.8|tRNA modification and maturation][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins]Gene
Coordinates
152,937 153,680
The protein
Catalyzed reaction/ biological activity
tRNA uridine38-40 --> tRNA pseudouridine38-40 (according to UniProt)Protein family
tRNA pseudouridine synthase TruA family (single member, according to UniProt)Structure
[PDB|1VS3] (from ''Thermus thermophilus'', 42% identity) [Pubmed|17114947]Additional information
[SW|universally conserved protein]Expression and Regulation
Operons
genes
[gene|84334531D66BE7524021C4B40C3FA05AAFE0D7A6|truA]-[gene|B495FFC63413D518138F8C2F3FBC894038C97E0E|rplM]-[gene|C8E45EDBCD0CFF353D1D66E6D77FD81E976BC0BC|rpsI]
description
[pubmed|22383849]
regulatory mechanism
[regulon|stringent response|stringent response]: negative regulation, [Pubmed|11948165], in [regulon|stringent response|stringent response]regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]view in new tabBiological materials
Mutant
BKE01480 ([gene|84334531D66BE7524021C4B40C3FA05AAFE0D7A6|truA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACAGCACCTCTAAGCCC, downstream forward: _UP4_TAAACCAGGTGTATAATATTBKK01480 ([gene|84334531D66BE7524021C4B40C3FA05AAFE0D7A6|truA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATACAGCACCTCTAAGCCC, downstream forward: _UP4_TAAACCAGGTGTATAATATTReferences
