SubtiBank SubtiBank
opuCB [2018-02-10T14:18:34.000Z]
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opuCB [2018-02-10T14:18:34.000Z]

glycine betaine/carnitine/choline/arsenobetaine/arsenocholine [SW|ABC transporter]
locus
BSU33820
pI
9.70
mw
23.00 kDa
protein length
217 aa Sequence Blast
gene length
651 bp Sequence Blast
function
compatible solute transport
product
glycine betaine/carnitine/choline/arsenobetaine/arsenocholine [SW|ABC transporter]
essential
no
synonyms
yvbD
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.1|Importers] → [category|SW 1.2.1.1.4|Uptake of compatible solutes for osmoprotection]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,469,184 → 3,469,837

    The protein

    Catalyzed reaction/ biological activity

  • uptake of glycine betaine, arsenocholine and arsenobetaine [pubmed|29159878]

    • Protein family

  • CysTW subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|70B45E7428DB1F6AEF7D2FE3062CC86BE96674FC|OpuBB]

    • [SW|Localization]

  • cell membrane [Pubmed|10092453]

    • Expression and Regulation

    Operons

    genes
    [gene|75DB6231129C28C5D3791BA43A1261CD46A861E8|opuCA]-[gene|83C45215AC86FACB08CF36EB5F9E6B076D7D0F0F|opuCB]-[gene|CBA6108A10AD8B932BC5B19A0E7982D0F56F1E08|opuCC]-[gene|76C8D6BF2CA1FA5E7392C52FFD55FD01EF5AB9DC|opuCD]
    description
    [Pubmed|10216873]

    regulatory mechanism

  • [protein|9F32E96AC9C32832C2F10FB125DDDC50EC9B546B|OpcR]: repression, (sterical interference with RNA polymerase access) [Pubmed|32849357,23960087], in [regulon|9F32E96AC9C32832C2F10FB125DDDC50EC9B546B|OpcR regulon]
  • [protein|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|RemA]: activation, [Pubmed|23646920], in [regulon|6AF1CB8998BE9C71DF4F1201A7F74FF7E75CB799|RemA regulon]
  • [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]

    • regulation

  • induced by salt stress [Pubmed|23960087,10216873]
  • induced in the absence of [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]
    • view in new tab

    Biological materials

    Mutant

  • BKE33820 (Δ[gene|83C45215AC86FACB08CF36EB5F9E6B076D7D0F0F|opuCB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33820 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTAAAAGAGCTCCTCC, downstream forward: _UP4_TCGTAAGGAGTTGGCACTGT
  • BKK33820 (Δ[gene|83C45215AC86FACB08CF36EB5F9E6B076D7D0F0F|opuCB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33820 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTTAAAAGAGCTCCTCC, downstream forward: _UP4_TCGTAAGGAGTTGGCACTGT

    • References

    Reviews

  • 27935846

    • Original publications

  • 10092453,9925583,10216873,21296969,23960087,23646920,29159878