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folC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
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folC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

folyl-polyglutamate synthetase
locus
BSU28080
pI
5.81
mw
48.00 kDa
function
biosynthesis of folate
product
folyl-polyglutamate synthetase
essential
no
ec
6.3.2.17
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors], [SW|membrane proteins]

    • This gene is a member of the following [SW|regulons]

  • [SW|T-box]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)

    • Protein family

  • folylpolyglutamate synthase family (according to Swiss-Prot)

    • Structure

  • [PDB|1FGS] (from ''Lactobacillus casei'', 32% identity, 51% similarity) [Pubmed|9618466]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|valS]-[protein|search|folC]'' [Pubmed|9098041]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9098041]

    • Regulation

  • induced by valine limitation ([protein|search|T-box]) [Pubmed|9098041]

    • Regulatory mechanism

  • [protein|search|T-box]: [SW|riboswitch], transcription termination/antitermination [Pubmed|9098041]

    • References

    Reviews

  • 19258532

    • Original Publications

  • 9098041