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folC [Mon Aug 31 2015 13:56:03 GMT+0200 (CEST)]
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folC [Mon Aug 31 2015 13:56:03 GMT+0200 (CEST)]

folyl-polyglutamate synthetase
locus
BSU28080
pI
5.00
mw
48.00 kDa
function
biosynthesis of folate
product
folyl-polyglutamate synthetase
essential
no
ec
6.3.2.17
synonyms

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis of cofactors], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|T-box]
  • Gene

    Coordinates on the chromosome (coding sequence)
    2,865,312 -> 2,866,604

    The protein

    Catalyzed reaction/ biological activity

  • ATP tetrahydropteroyl-(gamma-Glu)(n) L-glutamate = ADP phosphate tetrahydropteroyl-(gamma-Glu)(n1) (according to Swiss-Prot)
  • Protein family

  • folylpolyglutamate synthase family (according to Swiss-Prot)
  • Structure

  • [PDB|1FGS] (from ''Lactobacillus casei'', 32% identity, 51% similarity) [Pubmed|9618466]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|valS]-[protein|search|folC]'' [Pubmed|9098041]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9098041]
  • Regulation

  • induced by valine limitation ([protein|search|T-box]) [Pubmed|9098041]
  • Regulatory mechanism

  • [protein|search|T-box]: [SW|riboswitch], transcription termination/antitermination [Pubmed|9098041]
  • References

    Reviews

  • 19258532
  • Original Publications

  • 9098041