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folC [2019-04-15 18:58:56]
folyl-polyglutamate synthetase
function
biosynthesis of folate
product
folyl-polyglutamate synthetase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.5|Biosynthesis of folate][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
2,865,312 2,866,604
Phenotypes of a mutant
essential [Pubmed|28189581]The protein
Catalyzed reaction/ biological activity
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1) (according to Swiss-Prot)Protein family
folylpolyglutamate synthase family (according to Swiss-Prot)Structure
[PDB|1FGS] (from ''Lactobacillus casei'', 32% identity, 51% similarity) [Pubmed|9618466][SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|3E84B3AC08D0B314286CEF38534BD81B568F3E0E|valS]-[gene|80502F76F076C08CCE702F25095C06D14CD8154A|folC]
description
[Pubmed|9098041]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|9098041], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]regulatory mechanism
[regulon|T-box|T-box]: transcription termination/antitermination, via [SW|riboswitch], in [regulon|T-box|T-box]regulation
induced by valine limitation ([SW|T-box]) [Pubmed|9098041,19258532]the [SW|T-box] RNA is degraded by [protein|872CCB5A49C9000BD95E4B0472556D5F60F7D7A4|RNase Y] [pubmed|29794222]view in new tabReferences
Reviews
Original Publications
