6-phosphogluconate dehydrogenase
function
gluconate utilization
product
6-phosphogluconate dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.13|Utilization of gluconate][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|CcpA regulon], [SW|GntR regulon]Gene
Coordinates on the chromosome (coding sequence)
4,117,080 -> 4,118,486
The protein
Catalyzed reaction/ biological activity
6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH (according to Swiss-Prot)Protein family
6-phosphogluconate dehydrogenase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|GndA]Expression and Regulation
Operon
''[protein|search|gntR]-[protein|search|gntK]-[protein|search|gntP]-[protein|search|gntZ]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10746760 PubMed1] [http://www.ncbi.nlm.nih.gov/sites/entrez/3020045 PubMed2]''[protein|search|gntZ]'' [Pubmed|2419835][SW|Sigma factor]
''[protein|search|gntR]'': [protein|search|SigA] [Pubmed|3020045]''[protein|search|gntZ]'': [protein|search|SigA] [Pubmed|2419835]Regulation
induced by gluconate ([protein|search|GntR]) [Pubmed|3020045]repressed by glucose ([protein|search|CcpA]) [Pubmed|8370661]Regulatory mechanism
[protein|search|GntR]: transcription repression [Pubmed|3020045][protein|search|CcpA]: transcription repression [Pubmed|10666464][protein|search|AbrB]: transcription activation [Pubmed|20817675]References
10746760,8288545,3037520,3020045,3011959,8370661,3020045,1659648,220817675 
