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pncB [2019-07-10 09:11:55]

nicotinate phosphoribosyltransferase

locus

BSU31750

5.09

56.01 kDa

protein length

490 aa Sequence Blast

gene length

1473 bp Sequence Blast

function

NAD salvage

product

nicotinate phosphoribosyltransferase

essential

yes

2.4.2.11

synonyms

yueK

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]

[category|SW 2|Metabolism] → [category|SW 2.7|Detoxification reactions]

[category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates

3,259,403 3,260,875

Phenotypes of a mutant

essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

Protein family

NAPRTase family (according to Swiss-Prot)

Structure

[PDB|2F7F] (from ''Enterococcus faecalis'', 61% identity)

Expression and Regulation

Operons

genes

[gene|26430DCCEC263E7D03A3BBA4E7D636A250C3208B|pncA]-[gene|7CA7ADDBDDE46B0E6522704FD19C0BCF6FA9E058|pncB]

description

[Pubmed|22383849]

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genes

description

[Pubmed|22383849]

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Biological materials

Mutant

MGNA-B562 (yueK::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1561 NBRP B. subtilis, Japan]

References

16199587,9274030