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ftsL [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]
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ftsL [Tue Dec 13 2016 11:16:32 GMT+0100 (CET)]

cell-division protein (septum formation), controls together with EzrA dynamics of the FtsZ ring
locus
BSU15150
pI
10.00
mw
12.00 kDa
function
septum formation
product
cell-division protein
essential
yes
synonyms
ylxB, yllD

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|cell division], [SW|essential genes], [SW|membrane proteins]
  • Gene

    Coordinates on the chromosome (coding sequence)
    1,581,597 -> 1,581,950

    Phenotypes of a mutant

  • essential [Pubmed|12682299]
  • The protein

    Protein family

  • ftsL family (according to Swiss-Prot)
  • Effectors of protein activity

  • degraded by [protein|search|RasP], stabilized against [protein|search|RasP] cleavage by [SW|DivIC] [Pubmed|20644139]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • [SW|Interactions]

  • [protein|search|RasP]-[protein|search|FtsL], [SW|DivIC]-[protein|search|FtsL] [Pubmed|10844672]
  • [protein|search|PbpB]-[SW|DivIB]-([protein|search|FtsL]-[SW|DivIC])2 [Pubmed|20870765], as part of the [SW|divisome]
  • [protein|search|WalK]-[protein|search|FtsL] [Pubmed|21219466]
  • Expression and Regulation

    Operon

  • ''[protein|search|mraZ]-[protein|search|mraW]-[protein|search|ftsL]-[protein|search|pbpB]'' [Pubmed|8636036,8244929]
  • Regulation

  • constitutively expressed [Pubmed|23701187]
  • Additional information

  • FtsL is degraded by [protein|search|RasP] [PubMed|17020588]
  • Biological materials

    Mutant

  • MGNA-B127 (ylyB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1126 NBRP B. subtilis, Japan]
  • FLAG-tag construct

  • GP2004 ''ftsL-3xFLAG ermC'' (based on [SW|pGP1087]), available in [SW|Jörg Stülke]'s lab
  • References

    Reviews

  • 20836086
  • Original Publications

  • 9720875,10792716,16936019,16549676,17020588,8636036,10986263,11994149,10844672,19429628,20644139,21219466,23701187,20870765