two-component system response regulator, controls gene expression in response to cell density (concentration of ComX)
function
regulation of genetic competence and quorum sensing
product
two-component system response regulator
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|transcription factors and their control], [SW|quorum sensing], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
3,252,804 -> 3,253,448
The protein
Protein family
ComA family (according to Swiss-Prot)Modification
phosphorylated by [protein|search|ComP] on an Asp residueEffectors of protein activity
phosphorylation activates DNA bindingDNA-binding activity of ComA is inhibited by [protein|search|RapC] [Pubmed|12950917], [protein|search|RapD] [Pubmed|17227471], [protein|search|RapF] [Pubmed|15968044,22215984], [protein|search|RapH] [Pubmed|17581123] and [protein|search|RapK] [Pubmed|16816200]Structure
[PDB|1U83][PDB|3ULQ] (structure of the complex between the DNA-binding C-terminal domain of [protein|search|ComA] with [protein|search|RapF]) [Pubmed|22215984][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
[protein|search|RapC]-[protein|search|ComA] [Pubmed|12950917][protein|search|RapF]-[protein|search|ComA] [Pubmed|15968044,22215984][protein|search|RapH]-[protein|search|ComA] [Pubmed|17581123][protein|search|ComP]-[protein|search|ComA][SW|ComA]-[SW|RpoA] [Pubmed|26582911][SW|ComA]-[SW|SigA] [Pubmed|26582911]Expression and Regulation
Operon
''[protein|search|comA]-[protein|search|yuxO]'' [Pubmed|2507523][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2507523]References
Reviews
Original Publications
17227471,11133937,2116363,12067344,8387999,19202088,10094672,8643670,11267663,15968044,16816200,10447896,12950917,20302877,12270822,17581123,16816200,2507523,20208433,22215984,24130811,24425772,24788106,25598361,25757097,26582911,26787913,26927849 
