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gmuC [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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gmuC [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

glucomannan-specific phosphotransferase system, EIIC component of the PTS
locus
BSU05830
pI
9.80
mw
48.00 kDa
function
glucomannan uptake and phosphorylation
product
glucomannan-specific phosphotransferase system,
EIIC component
essential
no
synonyms
ydhO
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.25|Utilization of glucomannan]
  • [category|SW 6|Groups of genes] → [category|SW 6.11|Efp-dependent proteins]

    • [SW|Categories] containing this gene/protein

  • [SW|phosphotransferase systems], [SW|utilization of specific carbon sources]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|CcpA regulon], [SW|GmuR regulon], [SW|Efp-dependent proteins]

    • Gene

    Coordinates on the chromosome (coding sequence)
    627,284 -> 628,612

    The protein

    Protein family

  • [SW|PTS] permease, lactose permease (Lac) family [Pubmed|10627040]

    • Paralogous protein(s)

  • [protein|search|LicC], [protein|search|YwbA]

    • Structure

  • [PDB|3QNQ] (EIIC component of diacetylchitobiose specific PTS from ''Bacillus cereus''; 41% identity, 80% similarity) [Pubmed|21471968]

    • [SW|Interactions]

  • [protein|search|GmuB]-[protein|search|GmuC]

    • Expression and Regulation

    Operon

  • ''[protein|search|gmuB]-[protein|search|gmuA]-[protein|search|gmuC]-[protein|search|gmuD]-[protein|search|gmuR]-[protein|search|gmuE]-[protein|search|gmuF]-[protein|search|gmuG]'' [Pubmed|18177310]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|18177310]

    • Regulation

  • induced by conjac glucomannan (requires [protein|search|GmuG]) ([protein|search|GmuR]) [Pubmed|18177310]
  • induced by cellobiose ([protein|search|GmuR]) [Pubmed|18177310]
  • subject to carbon catabolite repression ([protein|search|CcpA]) [Pubmed|18177310]

    • Regulatory mechanism

  • [protein|search|GmuR]: transcription repression [Pubmed|18177310]
  • [protein|search|CcpA]: transcription repression [Pubmed|18177310]
  • [protein|search|AbrB]: transcription activation [Pubmed|20817675]

    • Additional information

  • [protein|search|translation] is likely to require [protein|search|Efp] due to the presence of several consecutive proline residues [PubMed|23239624,23239623]

    • References

  • 18177310,10627040,20817675,21471968