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hemE
uroporphyrinogen decarboxylase (uroporphyrinogen III)
function
heme biosynthesis
product
uroporphyrinogen decarboxylase (uroporphyrinogen III)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]Gene
Coordinates
1,086,117 1,087,178
The protein
Catalyzed reaction/ biological activity
4 H+ + uroporphyrinogen III --> 4 CO2 + coproporphyrinogen III (according to UniProt)Protein family
uroporphyrinogen decarboxylase family (single member, according to UniProt)Structure
[PDB|2INF][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]-[gene|E4C588EC93132CCBE4F40559F8A480A66A2D82D7|hemH]-[gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]
description
[Pubmed|1459957]
view in new tabBiological materials
Mutant
BKE10120 ([gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGATTTCCACCTTTCA, downstream forward: _UP4_TAAGCATATCTTTTGGTATCBKK10120 ([gene|762E7731EFEAC9F38074D7A7E9A3E5759437CDCA|hemE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10120 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTGATTTCCACCTTTCA, downstream forward: _UP4_TAAGCATATCTTTTGGTATCReferences
Reviews
Original Publications