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hemY

coproporphyrinogen oxidase

locus

BSU_10140

8.04

51.04 kDa

protein length

470 aa Sequence Blast

gene length

1413 bp Sequence Blast

function

biosynthesis of heme

product

coproporphyrinogen oxidase

essential

1.3.3.4

synonyms

hemG

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.6|Biosynthesis of heme/ siroheme]

[category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates

1,088,197 1,089,609

The protein

Catalyzed reaction/ biological activity

coproporphyrinogen --> coproporphyrin [pubmed|25646457]

3 O₂ + protoporphyrinogen IX --> 3 H₂O₂ + protoporphyrin IX (according to UniProt)

Protein family

Protoporphyrinogen oxidase family (single member, according to UniProt)

[SW|Cofactors]

FAD (according to UniProt)

Structure

[PDB|3I6D]

[SW|Localization]

cell membrane (peripheral) [pubmed|7928957]

Expression and Regulation

Operons

genes

description

[Pubmed|1459957]

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Biological materials

Mutant

BKE10140 ([gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE10140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCACTCATGTTCATCGCCT, downstream forward: _UP4_TAAAACCTCCGCTTTATCGC

BKK10140 ([gene|7541AD7D06BC4CE30AD576562E0053CC1E25B4D6|hemY]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK10140 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GTCACTCATGTTCATCGCCT, downstream forward: _UP4_TAAAACCTCCGCTTTATCGC

References

Reviews

28123057

Original Publications

9217019,1459957,7928957,19266155,19944166,22273380,25646457,8288631,28739897