HNH nuclease-like protein, rescues AddA-AddB-mediated recombination intermediates
function
rescuing of AddA-AddB-mediated recombination intermediates
product
HNH nuclease-like protein
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination][category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins][SW|Categories] containing this gene/protein
[SW|DNA repair/ recombination], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|ComK regulon]Gene
Coordinates on the chromosome (coding sequence)
1,148,155 -> 1,148,457
Phenotypes of a mutant
essential, the mutation can be suppressed by second-site mutations in ''[protein|search|addA]'' or ''[protein|search|addB]'' [Pubmed|22984257]The protein
[SW|Localization]
evenly distributed throughout the cytosol in growing cells [Pubmed|22984257]forms a single focus on the nucleoid upon induction of DNA damage [Pubmed|22984257]Expression and Regulation
Operon
''[protein|search|addB]-[protein|search|addA]-[protein|search|sbcD]-[protein|search|sbcC]-[protein|search|hlpB]'' [Pubmed|22383849]Regulation
positive regulation by [protein|search|ComK] [Pubmed|11948146]Biological materials
Mutant
MGNA-A503 (yisB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/503 NBRP B. subtilis, Japan]References
11948146,22984257,22383849 
