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ebrB
multidrug efflux transporter
function
multidrug resistance
product
multidrug efflux transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.14|Multidrug exporters][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
1,864,691 1,865,044
The protein
Protein family
paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072][SW|drug/metabolite transporter (DMT) superfamily] (according to UniProt)[SW|Small multidrug resistance (SMR) (TC 2.A.7.1) family] (according to UniProt)Paralogous protein(s)
[protein|53576746FF1B644A1980F8ACD0E8F4A54CDDAD83|EbrA] Structure
[PDB|3B5D] (EmrE from E. coli, 39% identity) [pubmed|18024586][SW|Localization]
cell membrane [Pubmed|17417881]Expression and Regulation
Operons
genes
[gene|53576746FF1B644A1980F8ACD0E8F4A54CDDAD83|ebrA]-[gene|74668FF19D097722D523CC54288B6409DE267631|ebrB]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B077 (ebrB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1076 NBRP B. subtilis, Japan]BKE17290 ([gene|74668FF19D097722D523CC54288B6409DE267631|ebrB]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE17290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCCTCTCATCTTCATCA, downstream forward: _UP4_GCCTGTGAGTGACCGTCTGTBKK17290 ([gene|74668FF19D097722D523CC54288B6409DE267631|ebrB]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK17290 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CAATCCTCTCATCTTCATCA, downstream forward: _UP4_GCCTGTGAGTGACCGTCTGTReferences
Reviews
Original publications
