You are currently viewing an outdated version of
SubtiWiki.
Please use
the newest version!
yhfR [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
phosphatase involved in isopentenol (isoprenoid) biosynthesis
function
isoprenoid biosynthesis
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.3|Biosynthesis of isoprenoids][SW|Categories] containing this gene/protein
[SW|biosynthesis of lipids]Gene
Coordinates on the chromosome (coding sequence)
1,108,736 -> 1,109,317
Phenotypes of a mutant
no detectable phenotype [Pubmed|10869096]The protein
Catalyzed reaction/ biological activity
phosphatase involved in isopentenol (isoprenoid) biosynthesisProtein family
GpmB subfamily (according to Swiss-Prot) similar to 2,3-diphosphoglycerate-dependent phosphoglycerate mutases [Pubmed|10869096]Structure
[PDB|1H2F] (enzyme of ''B. stearothermophilus'') [Pubmed|11827481]Additional information
The gene is annotated in KEGG as an ortholog of phosphoglycerate mutase (PGM) EC 5.4.2.1. In MetaCyc the protein is marked as “similar to phosphoglycerate mutase”. No EC annotation is available in Swiss-Prot. Pearson et al. ([Pubmed|10869096]) demonstrated that yhfR is non-essential for growth, sporulation, and spore germination. They also purified the gene, expressed it in ''B. subtilis'' but were not able to detect PGM activity in ''B. subtilis''. [Pubmed|19935659]Expression and Regulation
Operon
''[SW|yhfU]-[SW|yhfT]-[SW|yhfS]-[SW|yhfR]'' [Pubmed|22383849]''[SW|yhfT]-[SW|yhfS]-[SW|yhfR]'' [Pubmed|22383849]''[SW|yhfR]'' [Pubmed|22383849]Additional information
weakly expressed [http://www.ncbi.nlm.nih.gov/sites/entrez/10869096 PubMed]References
17693564,10869096,19935659,11827481,11514674 
