MarR/DUF24 family transcription repressor of azoR1, catD-catE and yodC expression
function
regulation of quinone and diamide detoxification
product
MarR/DUF24 family transcription repressor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress][SW|Categories] containing this gene/protein
[SW|transcription factors and their control], [SW|resistance against oxidative and electrophile stress]This gene is a member of the following [SW|regulons]
[SW|YodB regulon]Gene
Coordinates on the chromosome (coding sequence)
2,127,345 -> 2,127,683
Phenotypes of a mutant
increased resistance to catechol, quinones and diamide [Pubmed|20639328]The protein
Protein family
[[MarR/DUF24 family]]Paralogous protein(s)
[protein|search|CatR]Modification
redox-controlled by intersubunit disulfide formation of Cys6 and Cys101' in response to quinones and diamideEffectors of protein activity
responds distinctly to diamide or methyl-p-benzoquinone [Pubmed|27531959]Structure
[PDB|5HS7] (reduced form) [Pubmed|27531959][PDB|5HS8] (diamide-treated form) [Pubmed|27531959][PDB|5HS9] (quinone-bound form) [Pubmed|27531959]Expression and Regulation
Regulation
subject to autorepression [Pubmed|21749987]Regulatory mechanism
YodB: transcription repression [Pubmed|21749987]Additional information
responds distinctly to diamide or methyl-p-benzoquinone [Pubmed|27531959]Biological materials
Mutant
BKE19540 ''yodB''::''erm trpC2'' is available from the Bacillus Genetic Stock CenterLabs working on this gene/protein
[SW|Haike Antelmann],University of Greifswald, GermanyReferences
Reviews
Original Publications
17158660,17407181,18208493,20639328,20652907,21749987,27531959 
