UDP-N-acetyl-D-mannosamine transferase
function
biosynthesis of teichoic acid
product
UDP-N-acetyl-D-mannosamine transferase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.4|Biosynthesis of teichoic acid][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.3|Biosynthesis of teichoic acid][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|cell wall synthesis], [SW|biosynthesis of cell wall components]This gene is a member of the following [SW|regulons]
[SW|PhoP regulon], [SW|WalR regulon]Gene
Coordinates on the chromosome (coding sequence)
3,681,370 -> 3,682,140
Phenotypes of a mutant
essential [Pubmed|12682299], reduced growth rate, loss of rod-like morphology [Pubmed|19376878]inactivation of ''[protein|search|tagA]'' strongly restores beta-lactam resistance in a ''[protein|search|sigM]'' mutant [Pubmed|22211522]The protein
Catalyzed reaction/ biological activity
UDP-N-acetyl-D-mannosamine N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol (according to Swiss-Prot)Protein family
glycosyltransferase 26 family (according to Swiss-Prot)[SW|Localization]
secreted (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|tagA]-[protein|search|tagB]'' [Pubmed|7952180][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7581998]Regulation
repressed when phosphate is available ([protein|search|PhoP]) [Pubmed|9457886]Regulatory mechanism
[protein|search|PhoP]: transcription repression [Pubmed|9457886][protein|search|WalR]: transcription activation [Pubmed|12950927]References
Reviews
Original publications
18156271,9457886,9683503,7952180,7581998,19376878,12950927,22211522,25666134 
