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ykuQ
similar to tetrahydrodipicolinate succinylase
function
biosynthesis of lysine and peptidoglycan
product
similar to tetrahydrodipicolinate succinylase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan][category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.7|Biosynthesis/ acquisition of lysine/ threonine/ based on similarity][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]Gene
Coordinates
1,488,973 1,489,683
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
(S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H2O --> CoA + L-2-acetamido-6-oxoheptanedioate (according to UniProt)Protein family
[SW|Transferase hexapeptide repeat family] (according to UniProt)Structure
[PDB|3R8Y] (from ''Bacillus anthracis'', 80% identity, 96% similarity)Expression and Regulation
Operons
genes
[gene|716FE06124544C05CC34BA2E643B4DBD27F04998|ykuQ]-[gene|D6F1906CE8386F78F451D6B794F74DE4AD25AC9C|ykuR]-[gene|3E7E0342AA86AFCC95F5CD5BEA5B10166DCE2721|ykuS]
description
[Pubmed|22383849]
Biological materials
Mutant
MGNA-B340 (ykuQ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1339 NBRP B. subtilis, Japan]
