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thyA

thymidylate synthase A

locus

BSU_17680

5.50

32.65 kDa

protein length

279 aa Sequence Blast

gene length

840 bp Sequence Blast

function

biosynthesis of thymidine nucleotides

product

thymidylate synthase A

essential

2.1.1.45

synonyms

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]

Gene

Coordinates

1,902,219 1,903,058

The protein

Catalyzed reaction/ biological activity

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP --> 7,8-dihydrofolate + dTMP (according to UniProt)

Protein family

thymidylate synthase family (with [protein|9F9643D51E9ABA537892B19312491697CECDDCCF|ThyB], according to UniProt)

Paralogous protein(s)

[protein|9F9643D51E9ABA537892B19312491697CECDDCCF|ThyB]

Structure

[PDB|1B02] [pubmed|10091656]

[SW|Localization]

cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

genes

[gene|6FE1D3C4D4DF86DE2D3D9A143A1DCFE120F13F5F|thyA]

description

[Pubmed|22383849]

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Biological materials

Mutant

BKE17680 ([gene|6FE1D3C4D4DF86DE2D3D9A143A1DCFE120F13F5F|thyA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE17680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTATTCATATCCTTC, downstream forward: _UP4_TAATGCTGCCTTTTTATTGT

BKK17680 ([gene|6FE1D3C4D4DF86DE2D3D9A143A1DCFE120F13F5F|thyA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK17680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGACTATTCATATCCTTC, downstream forward: _UP4_TAATGCTGCCTTTTTATTGT

References

Reviews

7574499

Original publications

418407,11267663,28700593,10091656,7704257,9648749,111614,29150519