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ytkP

similar to cysteine synthase

locus

BSU_29970

4.93

32.91 kDa

protein length

311 aa Sequence Blast

gene length

933 bp Sequence Blast

function

unknown

product

unknown

essential

2.5.1.47

synonyms

Outlinks

KEGG BsubCyc SubtiList UniProt Expression Browser

Genomic Context

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categories

[category|SW 6|Groups of genes] → [category|SW 6.6|Poorly characterized/ putative enzymes]

Gene

Coordinates

3,066,451 → 3,067,386

The protein

Catalyzed reaction/ biological activity

O(3)-acetyl-L-serine + H₂S --> L-cysteine + acetate (according to UniProt)

Protein family

Cysteine synthase/cystathionine beta-synthase family (with [protein|D1FC976597E5583E40A4ED7234FBCA743AB01354|CysK] and [protein|F195C47849F4F6B4C56E3A386F5D8C84326B01C4|MccA], according to UniProt)

Paralogous protein(s)

[protein|D1FC976597E5583E40A4ED7234FBCA743AB01354|CysK], [protein|F195C47849F4F6B4C56E3A386F5D8C84326B01C4|MccA]

[SW|Cofactors]

PLP (according to UniProt)

Structure

[PDB|2EGU] (from Geobacillus Kaustophilus 57% identity)

[SW|Localization]

cytoplasm (according to UniProt)

Expression and Regulation

Operons

genes

[gene|6F1462EA074DEDE2FEF13561A6691A22BFAD10FE|ytkP]

description

[Pubmed|22383849]

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Biological materials

Mutant

MGNA-B534 (ytkP::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1533 NBRP B. subtilis, Japan]

BKE29970 (Δ[gene|6F1462EA074DEDE2FEF13561A6691A22BFAD10FE|ytkP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCATTCCTTTCTGAA, downstream forward: _UP4_TAAAAAAAGGACTGGCTTCA

BKK29970 (Δ[gene|6F1462EA074DEDE2FEF13561A6691A22BFAD10FE|ytkP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTCATTCCTTTCTGAA, downstream forward: _UP4_TAAAAAAAGGACTGGCTTCA