SubtiBank SubtiBank
pyrR [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

pyrR [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

transcriptional antiterminator of the pyr operon
locus
BSU15470
pI
4.99
mw
20.00 kDa
function
regulation of pyrimidine biosynthesis
product
transcriptional antiterminator with minor uracil
phosphoribosyltransferase activity
essential
no
ec
2.4.2.9
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.4|Biosynthesis/ acquisition of pyrimidine nucleotides]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.4|RNA binding regulators]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of nucleotides], [SW|transcription factors and their control], [SW|RNA binding regulators]

    • This gene is a member of the following [SW|regulons]

  • [SW|PyrR regulon]

    • The protein

    Catalyzed reaction/ biological activity

  • UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

    • Protein family

  • PyrR subfamily (according to Swiss-Prot)

    • Structure

  • [PDB|1A3C] (dimeric form)

    • [SW|Interactions]

  • [protein|search|PyrR]-[protein|search|PyrR] [Pubmed|9551555]

    • Expression and Regulation

    Operon

  • ''[protein|search|pyrR]-[protein|search|pyrP]-[protein|search|pyrB]-[protein|search|pyrC]-[SW|pyrAA]-[SW|pyrAB]-[protein|search|pyrK]-[protein|search|pyrD]-[protein|search|pyrF]-[protein|search|pyrE]'' [Pubmed|8206849]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|1709162]

    • Regulation

  • induced in the absence of uridine nucleotides ([protein|search|PyrR]) [Pubmed|8206849]

    • Regulatory mechanism

  • [protein|search|PyrR]: [SW|RNA switch], transcription termination/ antitermination (in the presence of uridine nucleotides: termination, in their absence: antitermination) [Pubmed|8955403]

    • References

  • 8935652,8206849,15716449,11726695,9488732,9551555,12896995,9932459,8955403,8824632,12482852,1709162,7798145,11948166,8759868,7868607,9488732,17322189