N-acetylmuramoyl-L-alanine amidase, required for flagellar function
function
major autolysin, cell separation, wall turnover
product
N-acetylmuramoyl-L-alanine amidase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.1|Autolysis][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.1|Motility and chemotaxis] → [category|SW 4.1.1.4|Motility and chemotaxis/ other][SW|Categories] containing this gene/protein
[SW|cell wall degradation/ turnover], [SW|motility and chemotaxis]This gene is a member of the following [SW|regulons]
[SW|SigD regulon], [SW|SlrR regulon], [SW|YvrHb regulon]Gene
Coordinates on the chromosome (coding sequence)
3,659,119 -> 3,660,609
Phenotypes of a mutant
impaired in motility, the phenotype is suppressed by mutations in ''[protein|search|lonA]'' or ''[protein|search|smiA]'' [Pubmed|19542270]The protein
Catalyzed reaction/ biological activity
Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (according to Swiss-Prot)Protein family
N-acetylmuramoyl-L-alanine amidase 3 family (according to Swiss-Prot)[SW|Domains]
contains an amidase_3 domain (like [protein|search|CwlC], [protein|search|CwlD], [protein|search|YqiI], [protein|search|YrvJ])[SW|Localization]
secreted (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|lytA]-[protein|search|lytB]-[protein|search|lytC]'' [Pubmed|1357079][SW|Sigma factor]
[protein|search|SigA] [Pubmed|1357079], [protein|search|SigD] [Pubmed|1357079]Regulatory mechanism
[SW|YvrHb]: transcription repression [Pubmed|16306698][protein|search|SlrR] (in complex with [protein|search|SinR]: transcription repression [Pubmed|20351052]Biological materials
Mutant
1A789 ( ''lytC''::''kan''), [Pubmed|1588906], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A789&Search=1A789 BGSC]References
19542270,10945275,14594841,1357079,16306698,20351052,9158733,27118079 
