3-hydroxy-1-pyrroline-5-carboxylate dehydrogenase
function
arginine, ornithine and citrulline utilization
product
3-hydroxy-1-pyrroline-5-carboxylate dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.4|Utilization of arginine/ ornithine][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.8|Phosphorylation on either a Ser, Thr or Tyr residue][SW|Categories] containing this gene/protein
[SW|utilization of amino acids], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|AhrC regulon], [SW|CodY regulon], [SW|RocR regulon], [SW|SigL regulon]Gene
Coordinates on the chromosome (coding sequence)
3,878,966 -> 3,880,513
The protein
Catalyzed reaction/ biological activity
(S)-1-pyrroline-5-carboxylate NAD(P) 2 H2O = L-glutamate NAD(P)H (according to Swiss-Prot) Protein family
RocA subfamily (according to Swiss-Prot)Paralogous protein(s)
[protein|search|PutC], additional similar proteins: [protein|search|YfmT], [protein|search|AldY], [protein|search|YcbD], [protein|search|GabD], [protein|search|GbsA], [protein|search|DhaS], [protein|search|IolA], [protein|search|AldX], [protein|search|YwdH]Modification
phosphorylation on (Thr-2 OR Thr-4 OR Tyr-5) [Pubmed|17218307]Structure
[PDB|3RJL] (1-pyrroline-5-carboxylate dehydrogenase from ''Bacillus licheniformis'', 68% identity, 88% similarity)Expression and Regulation
Operon
''[protein|search|rocA]-[protein|search|rocB]-[protein|search|rocC]'' [Pubmed|8113162][SW|Sigma factor]
[protein|search|SigL] [Pubmed|8113162]Regulation
induction by arginine ([protein|search|RocR], [protein|search|AhrC]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8113162,7565595 PubMed]repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|12618455]Regulatory mechanism
[protein|search|CodY]: transcription repression [Pubmed|12618455][protein|search|RocR]: transcription activation [Pubmed|8113162][protein|search|AhrC]: transcription activation [Pubmed|7565595][protein|search|AbrB]: transcription repression [Pubmed|20817675]References
7565595,12618455,8113162,17218307,20817675 
