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mrgA [Mon Aug 31 2015 13:56:44 GMT+0200 (CEST)]
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mrgA [Mon Aug 31 2015 13:56:44 GMT+0200 (CEST)]

iron storage protein, DNA-binding stress protein, forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing
locus
BSU32990
pI
4.60
mw
17.00 kDa
function
iron storage,
product
mini-ferritin, DNA-binding stress protein
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.3|Homeostasis] → [category|SW 1.3.3|Acquisition of iron] → [category|SW 1.3.3.3|Acquisition of iron / Other]
  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.1|Acquisition of iron / Other]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.8|Resistance against oxidative and electrophile stress]
  • [SW|Categories] containing this gene/protein

  • [SW|acquisition of iron], [SW|iron metabolism], [SW|resistance against oxidative and electrophile stress]
  • This gene is a member of the following [SW|regulons]

  • [SW|PerR regulon]
  • The protein

    Catalyzed reaction/ biological activity

  • forms highly stable, multimeric protein-DNA complexes which protect against oxidative killing
  • Protein family

  • dps family (according to Swiss-Prot)
  • Paralogous protein(s)

  • [protein|search|Dps]
  • [SW|Cofactors]

  • contains an iron-sulfur cluster
  • Structure

  • [PDB|2CHP]
  • Expression and Regulation

    Operon

  • ''mrgA'' [Pubmed|8396117]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|14563870]
  • Regulation

  • induced by hydrogen peroxide ([protein|search|PerR]) [Pubmed|11532148]
  • Regulatory mechanism

  • [protein|search|PerR]: transcription repression [Pubmed|11532148]
  • References

    Reviews

  • 15222465
  • Original publications

  • 9393687,14563870,7667267,12486061,8396117,9393707,8709848,8932315,11532148