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kre
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK] repressor, stimulates degradation of the [gene|search|comK ]mRNA
function
control of [protein|search|ComK ]accumulation and of bistable competence gene expression
product
[protein|search|ComK ]repressor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue]Gene
Coordinates
1,474,560 1,475,024
The protein
Catalyzed reaction/ biological activity
stimulates [protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK] mRNA degradation [Pubmed|26110430]controls stability of several mRNAs (see [SW|Kre regulon]) [Pubmed|26110430][SW|Localization]
cytoplasm [Pubmed|26110430]Expression and Regulation
Operons
genes
[gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]
description
[Pubmed|8169223]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK]: repression, [Pubmed|26110430], in [regulon|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|ComK regulon]regulation
repressed in competent cells ([SW|ComK]) [Pubmed|26110430]view in new tabBiological materials
Mutant
MGNA-A764 (ykyB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/764 NBRP B. subtilis, Japan]PG479 (ykyB::erm), available in [SW|Leendert Hamoen]'s and [SW|Jörg Stülke]'s labs [Pubmed|26110430]GP2533 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::''erm''), available in [SW|Jörg Stülke]'s labBKE14020 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE14020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCTCTCCTTTGCT, downstream forward: _UP4_TAAAATAAAAACAGCCGTGCBKK14020 ([gene|65E2F7197D46F5C884CC96018EE4F3EEE94FFA18|kre]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK14020 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTATTTCTCTCCTTTGCT, downstream forward: _UP4_TAAAATAAAAACAGCCGTGCReferences
Reviews
Original Publications