DNA polymerase III (alpha subunit), part of the replisome
product
DNA polymerase III (alpha subunit)
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|DNA replication], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|LexA regulon]Gene
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to Swiss-Prot)required for bacteriophage SPP1 replication [Pubmed|23268446]Protein family
DnaE subfamily (according to Swiss-Prot)Structure
[PDB|3E0D] (from ''Thermus aquaticus'', 39% identity) [Pubmed|18691598][SW|Localization]
forms foci, the foci dissappear after the formation of DNA mismatches in a [protein|search|MutS]-dependent manner or after DNA replication arrest [Pubmed|21958350]cytoplasm (according to Swiss-Prot)[SW|Interactions]
part of the [SW|replisome]: [protein|search|PolC]-[protein|search|HolA]-[protein|search|HolB]-[protein|search|DnaX]-[protein|search|DnaN]-[protein|search|DnaG]-[protein|search|DnaC]-[protein|search|DnaI]-[protein|search|DnaD]-[protein|search|SsbA]-[protein|search|DnaE]-[protein|search|PriA]-[protein|search|DnaB] [Pubmed|20122408][protein|search|DnaE]-[protein|search|MutL] [Pubmed|21958350][protein|search|DnaE]-[protein|search|MutS] [Pubmed|21958350][protein|search|DnaE]-[protein|search|DnaN] [Pubmed|21958350][protein|search|DnaE]-[protein|search|SsbA] [Pubmed|21958350][protein|search|DnaE]-[protein|search|DnaC] [Pubmed|23563155][protein|search|DnaE]-[protein|search|DnaG] [Pubmed|23563155][protein|search|DnaE]-[protein|search|HolA] [Pubmed|23563155][protein|search|DnaE]-[protein|search|PolC] [Pubmed|23563155]Expression and Regulation
Operon
''[protein|search|dnaE]'' (according to [http://dbtbs.hgc.jp/COG/prom/dnaE.html DBTBS])Regulation
induced by DNA damage ([protein|search|LexA]) [http://www.ncbi.nlm.nih.gov/sites/entrez/14593098,16267290 PubMed]Regulatory mechanism
[protein|search|LexA]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/14593098,16267290 PubMed]References
Reviews
Original publications
11721055,14593098,16267290,20122408,23563155,23017159,21958350,23268446,24062730,24106089,18691598 
