transcriptional repressor (MerR family) of the glnR-glnA operon
function
regulation of glutamine synthesis
product
transcription repressor (MerR family)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.1|Biosynthesis/ acquisition of glutamate/ glutamine/ ammonium assimilation][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|glutamate metabolism], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|GlnR regulon], [SW|TnrA regulon]Gene
Coordinates on the chromosome (coding sequence)
1,877,959 -> 1,878,366
The protein
Protein family
[SW|MerR family][SW|Cofactors]
feedback-inhibited [protein|search|GlnA] [Pubmed|18195355]Effectors of protein activity
activity is enhanced upon interaction of the C-terminal domain with [protein|search|GlnA] [Pubmed|18331450]Structure
[PDB|4R4E] (the GlnR-DNA complex) [Pubmed|25691471][SW|Interactions]
[protein|search|GlnR]-[protein|search|GlnA], with feedback-inhibited [protein|search|GlnA], this results in DNA binding [Pubmed|18195355]Expression and Regulation
Operon
''[protein|search|glnR]-[protein|search|glnA]'' [Pubmed|8636055][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2906311]Regulation
expressed in the absence of glutamine ([protein|search|GlnR]) [Pubmed|8636055]repressed in the absence of good nitrogen sources (glutamine or ammonium) ([protein|search|TnrA]) [Pubmed|8799114]Regulatory mechanism
[protein|search|GlnR]-[protein|search|GlnA] complex: transcription repression [Pubmed|8636055][protein|search|TnrA]: transcription repression [Pubmed|8799114]Biological materials
Mutant
BP148 (del(''[protein|search|glnR]-[protein|search|glnA]'')::''cat''), available in [SW|Fabian Commichau]'s lablacZ fusion
pGP189 (in [protein|search|pAC7]), available in [SW|Jörg Stülke]'s labLabs working on this gene/protein
[SW|Susan Fisher], Boston, USA [http://www.bumc.bu.edu/microbiology/research/susan-h-fisher-phd/ homepage]References
Reviews
Original publications
12374841,9287005,8799114,18195355,2573733,8636055,19233925,2906311,18331450,16547045,23535029,25691471,25755103 
