two-component response regulator (OmpR family), regulation of phosphate metabolism
function
regulation of phosphate metabolism
(phoA, phoB, phoD, resA | resABCDE, tagA-tagB, tagD | tagDEF, tuaA | tuaA-H)
product
two-component response regulator (OmpR family)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.3|Phosphate metabolism][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.5|Regulators of core metabolism][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue][SW|Categories] containing this gene/protein
[SW|phosphate metabolism], [SW|transcription factors and their control], [SW|regulators of core metabolism], [SW|sporulation proteins], [SW|general stress proteins (controlled by SigB)], [SW|membrane proteins], [SW|phosphoproteins]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|PhoP regulon], [SW|SigB regulon], [SW|SigE regulon]The protein
Protein family
[SW|OmpR family] of two-component response regulatorsModification
phosphorylation by [protein|search|PhoR] under conditions of phosphate limitation (stimulates DNA-binding activity)Effectors of protein activity
phosphorylation stimulates DNA-binding activityStructure
[PDB|1MVO] (receiver domain)[SW|Localization]
cell membrane (according to Swiss-Prot)[SW|Interactions]
[protein|search|PhoP]-[protein|search|PhoP], [protein|search|PhoP]-[protein|search|PhoR]Expression and Regulation
Operon
''[protein|search|phoP]-[protein|search|phoR]'' [Pubmed|14762014][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16452408], [protein|search|SigB] [Pubmed|15205429], [protein|search|SigE] [Pubmed|15699190,15205429]Regulation
carbon catabolite repression ([protein|search|CcpA]) [Pubmed|16452408,12850135]expressed under conditions of phosphate limitation ([protein|search|PhoP]) [Pubmed|25666134,15205429,14762014]expressed in post-exponential phase ([protein|search|ScoC]) [Pubmed|20382764]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|16452408,12850135][protein|search|PhoP]: transcription activation, due to [protein|search|PhoP]~P binding to the 3’end of the ''[protein|search|phoP]-[protein|search|phoR]'' operon [Pubmed|25666134,15205429,14762014][protein|search|ScoC]: transcription repression [Pubmed|20382764]Biological materials
Mutant
1A966 ( ''phoP''::''tet''), [Pubmed|14973033], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A966&Search=1A966 BGSC]Labs working on this gene/protein
[SW|Marion Hulett], University of Illinois at Chicago, USA [http://www.uic.edu/depts/bios/faculty/hulett/hulettm.shtml Homepage]References
Regulation of ''[SW|phoP]]-[[phoR]'' expression
20382764,14762014,12850135,15205429,16452408,25666134 Biochemical analyses
9680208,9611818,12486063,20167622,10433720,17085571,14973033,12486062 Targets of PhoR==
Additional publications:''' [Pubmed|21636651]20059685 16030210, 10913081,10094677,9683503,9988472,9457886,9335276,9593301,9098050, Other original publications
